To clarify your Mac Mini has two ports one SATA were a standard 2.5" HDD or SSD will work and one Apple custom blade SSD.
It is not able to support a M.2 compliant SSD. So the answer is no you can't use a M.2 SSD in your Mac Mini.
But! You can add in the custom SSD cable and the custom SSD unit (the OWC Aura SSD in the link is also designed to work as well).
Here's a useful reference The Ultimate Guide to Apple’s Proprietary SSDs
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