Even in the 2010 Model of Mini, the system bus is 1066Mhz, so I believe that you can use this RAM, but your system is only going to recognize 1066mhz, its an EFI limitation on your logicboard itself. On a PC you would be able to fiddle around with the bios and allow the machine to recognize all 1333 MHZ, but the difference wont be noticeable. I wouldn.t recommend that you use RAM that isn't exactly specific to your mini's specs. If you have a 2007 or earlier model then the memory is DDR2, which is definitely not compatible with the RAM u mention.