Snip the two sets of wires that are attached to the motherboard. Cut the wires as close to the board as possible. This will leave plenty of length to reattach the wires to the new board.

Skip this step if you are only removing the motherboard to replace the screen.

During reassembly, we recommend soldering or crimping the wires away from the motherboard contacts. You should avoid soldering directly to the motherboard unless absolutely necessary. To learn more about soldering, check out iFixit's Soldering Skills Guide