Once the splash screen is closed, you will be presented with Blender's main UI. You might feel overwhelmed by the many panels, but their are only a few different areas you should be aware of.

Blender's user interface is divided into three separate parts...

Topbar: The Topbar is at the very top of Blender's window, and consists of the main menu. It is used for saving your progress, importing and exporting files, configuring settings, and rendering scenes. The Topbar is also where you will find different Workspaces.

Areas: Areas are in the center of the window, and will be your main workspace.

Status Bar: Located at the bottom of the screen, the Status Bar displays shortcut suggestions, along with relevant statistics about your Areas.