Apply any tire insert, such as Tube Defender from flattiredefender, or Mr. Tuffy tire liner. I haven't experimented yet.

Insert the tube into the tire. If there is a direction-of-travel arrow on the side of the tire, it should point opposite the direction of the valve stem.

Some tread patterns are optimized for shedding water and mud in a direction of travel and are marked with an arrow on the sidewall.

The valve stem needs to point away from the direction of travel to protect it from snagging on any foreign objects.

Inspect that the tube is not twisted