no, everything will work fine, with the exception of the Touch ID. if your new screen came with a home button, it will work as a home button only. original home buttons come from the Apple factory mated (by serial number) to the motherboard. if your new screen did not come with a home button, then you would need to transfer yours and you will retain Touch ID.
not replacing the components with the original won’t matter in a 6s. sure if you do a Verification Report in 3uTools, it will report that those components are not original, but they’ll work all the same.
i believe iPhone X were the last ones that we could do DIY repairs with out the phone itself wigging out and not working with the new parts.
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