First you'll need to review your systems current CPU and socket then, review the CPU you have to see if it's compatible. Don't forget the Max TDP can't be larger for the new chip.
Here's the tools I use:
So here's what I find:
Intel Core 2 Duo Processor E7600 (3M Cache, 3.06 GHz, 1066 MHz FSB)
Intel Core 2 Quad Processor Q9450 (12M Cache, 2.66 GHz, 1333 MHz FSB)
While the sockets needed are the same (LGA775)
The FSB Speeds are different: 1066 MHz Vs 1333 MHz. The controller logic chips won't support the higher speed.
And lastly, the Max TDP is not the same: 65 Watts Vs 95 Watts. Which means the power supply and system cooling won't support the added load.
Bottom line here: These two chips are not interchangeable in this system. Sorry ;-{
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