This guide should not be rated moderate because everything is straight forward. The trickiest step was removing the keyboard. Once it is disassembled to the point of replacing the hard drive, you can also replace pretty much everything else also.
I have had the need to replace the cd assembly on a few 360 e-models. The problem I run into occasionally is the new cd assembly will sometimes only play music discs. I'm not sure if there is a software lock on the assembly or not as installing a 2nd new drive fixes the problem. Are some 360 drive assemblies not compatible with certain mobo revisions? Also, once you get the sides off, a very long screwdriver does the trick on the clips to get it open.