As far as I know, these are the issues and potential work-arounds for built-in applications, but if you have an issue with some other application, drop a comment down below.

So, let's dive into some applications that you will download, starting with Apple's Applications.

GarageBand simply doesn't work. It requires Metal Graphics to load the timeline. If you want to use GarageBand, you must download an older version.

iMovie also simply does not work. It too requires Metal Graphics to render video playback. You will also have to download and older version if you want to use it.

Pages, on the other hand, works flawlessly. I personally have not experienced any issues with running the latest version of Pages.

Numbers, too, works flawlessly. I have not had much experience using Numbers, but I have not encountered any issues.

Keynote works great until you want to present it. The app (or maybe even the computer) will crash when you try to preview a transition or present the keynote itself. You can edit fine, but if you want to present the keynote from the Mac, you will have to download an older version.