Use your compressed air can to blow away loose dust from the motherboard.
Follow the instructions on your compressed air can. Generally, you will hold the nozzle 3-4 inches from the target, right side up, and only apply short bursts of air.
Do not blow compressed air near the fan assembly without holding the fan still, as this can spin the fan blades at high speed and generate a damaging voltage.
If you are wearing a grounded anti-static bracelet, you can remove larger chunks of dust by hand.
If you have an anti-static brush, you can use it to dust away or loosen dust before blasting it away with the air.
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