The I/O boards are held in place by Phillips head thumbscrews and can be loosened (and tightened) by hand. But our trusty Manta Driver Kit is always here to assist.

All PCIe cards are locked in place by a single switch (handily labeled as step 2).

This switch moves a rail with little hooks on it that secure anything in their path. In other words: one switch to remove them all, one switch to bind them.