Giant Reign 2 Hydraulic Brake Fluid Replacement

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Pull out and rotate the quick release lever until the axle is loose.
Pull back on the derailleur on the left hand side. This lessens the force required to remove the wheel from its mount greatly.
Lift the bike, and pull the wheel from its mount.
It is possible that your wheel does not have a quick release tab. In this case, use a wrench to loosen the retaining bolt. This wrench size varies between wheels.

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