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- Power Capacity: The 650S offers significantly more overhead, supporting up to 410 Watts, making it suitable for modern desktop PCs, whereas the 280S is best reserved for networking gear (routers/modems).
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- Battery Requirements: Both the 280S and 420S utilize the RBC2 battery (12V 7Ah). The 650S requires the larger RBC4 (12V 12Ah) to achieve its higher wattage and runtime.
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- Physical Footprint: The 650S is notably heavier and larger due to its higher-capacity transformer and larger internal battery.