I had this issue and took it down to the basics, interestingly for a moment after rebooting I was able to click in the previously un-clickable area in my case the right side of the screen. So I thought well it’s gotta be one of the startup items. I removed what I could from login items and restarted. Same issue however I did notice that grammerly was running in the menu bar. Quit this and issue resolved immediately. Won’t be the same for everybody but worth following the same path to a solution hopefully.