Maybe the grounded wire to the frame is pulling electricity to the ground and blows the fuse, just insulate wherever youd be touching with it turned on.
Maybe youre trying to use more power than possible on one speaker port or to the whole thing. Wire all the red together and all the black together separately then wire all your speakers reds together and then all the black then hook it to the amp, but only if you know your amp can handle that many watts, speakers just pull electricity to them. Some resistors or transistors will fry if too much power gets drawn threw them do you have to check them or pretest equipment before shows.