Hey Alex! It sounds like either an issue with the motherboard, or an issue with your operating system. I’d say it’s likely the motherboard headers. Since you built this PC, I imagine you know your way around it, so I’ll give you a straight answer here. Try taking the side panel off and messing with the USB headers, maybe blow out the connectors, or try reseating it at the very least. Also, do your front panel audio jacks work? If it’s a motherboard issue, they’d likely have some sort of issues. Good luck!