I had the same problem with amazon loading to the home screen and the firestick remote not working or letting me navigate from there. I tried unplugging everything and plugging it back in, changed the batteries 3 times, held every button for 5, 10, 60 seconds but got nothing.. until I held down the MIC button and it popped up on the tv and surprisingly the remote started working from there. I have no idea why that fixed the problem, but it did.