Do you mean the screen is "touching" (as if you had touched) screen commands on it's own? That is usually indicative of a poor quality replacement screen. Have you tried multiple different screens or have you just re-installed the same screen multiple times?
Is this following a screen replacement due to a cracked screen? If so, you should try to re-install the cracked screen to see if the problem is still there.
Finally, try using the screen without it being fully installed into the housing. There may be some pressure points that only show up when the screen is fully fitted in the housing.