I just did the same model, with digitizer from iFixit, and the bottom 1/4 of the screen is unresponsive. I spent extra time making sure everything went perfectly for this customer, and the part let me down. It is running the latest version of iOS, and I know that was a cause of some iPhone's having issues after a new digitizer and/or home button were replaced. I would think the whole digitizer would not work if that was the cause.
I'm going to make a claim with iFixit and see how that goes.