What u can actually do if u have been using ur pc for long is this procedure.
Fisrt if u are gona use ccleaner really have a backup of ur registry becouse it will mess up lots of times,, even more when u have a fragmentet hdd
so if u want to really do a Core tune up start from the core, your OS
Basically decide on what aplication u have installed u will use and what u will not.
What u will not uninstall it using a freeware uninstaller,in ur case Revo uninstaller will do becouse it has the option to delete registry keys and folder & files left by the program.Leave just alpications u use.
The second one optional at this point defrag and clean up
tool u will find in any windows and if u think u have a worse state than that skip this and get in ur pc a window cd,ur windows version cd to be precise
And make a repair of the pc,this will delete ur system replace it with a new one and not delete user files.After u start up start ur antivirus software and nothing else this will make the RE-WRITE of the antivirus software in the registry update if u have not and make a scan any virus wont have an escape this way becouse ur registry is fresh free now and no virus has accessed it yes.
After virus free machine just start up in ur aplications from the folders in program files.they will be there .they will also re-write themselfes in the registry,make shortcuts on desktop if u need, and after this defrag if needed.MAke a cleanup with the windows tool that is needed for sure.
100% sure this will give u a much more faster fresher and beter OS nad PC