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crwdns2934241:0crwdne2934241:0 laraine stokes

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I have had this problem twice on my GS 450H.  The solution which worked for me is simple.  Remove the manual key from the key fob and insert into driver's door.  Turn the key left and hold for 2 seconds.  It works!!!

There are many complicated solutions online -  try this one first.

Good luck

Laraine

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